Accessing gap-junction channel structure-function relationships through molecular modeling and simulations
نویسندگان
چکیده
منابع مشابه
Molecular modeling and mutagenesis of gap junction channels.
Gap junction channels connect the cytoplasms of adjacent cells through the end-to-end docking of hexameric hemichannels called connexons. Each connexon is formed by a ring of 24 alpha-helices that are staggered by 30 degrees with respect to those in the apposed connexon. Current evidence suggests that the two connexons are docked by interdigitated, anti-parallel beta strands across the extracel...
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The unitary conductances and permeability sequences of the rat connexin40 (rCx40) gap junction channels to seven monovalent cations and anions were studied in rCx40-transfected neuroblastoma 2A (N2A) cell pairs using the dual whole cell recording technique. Chloride salt cation substitutions (115 mM principal salt) resulted in the following junctional maximal single channel current-voltage rela...
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Gap junction membrane channels mediate electrical and metabolic coupling between adjacent cells. The structure of a recombinant cardiac gap junction channel was determined by electron crystallography at resolutions of 7.5 angstroms in the membrane plane and 21 angstroms in the vertical direction. The dodecameric channel was formed by the end-to-end docking of two hexamers, each of which display...
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Communication plays an important role in the rapid Connexin Structure progress of modern society. We live in an age when Gap junctions exhibit a hierarchy of assembly. The prininformation is transmitted through many different pathcipal structural component, the membrane protein conways and in many different forms to influence our daily nexin, is organized into the basic unit of structure, the d...
متن کاملOn gap junction structure
We have studied the stain distribution within rat liver gap junctions for specimens prepared by thin sectioning and negative staining. Pools of stain molecules exist in two specific locations with respect to the distinctive morphological units (connexons) of the junction. One pool of stain surrounds the connexons and is restricted to the extracellular space in the gap between the adjacent plasm...
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ژورنال
عنوان ژورنال: BMC Cell Biology
سال: 2017
ISSN: 1471-2121
DOI: 10.1186/s12860-016-0121-9